Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | SV Rödinghausen | KFC Uerdingen | 0-1 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | SC Fortuna Köln | VfB Homberg | 1-1 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | Bor. Mönchengladbach II | Alemannia Aachen | 3-2 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | Sportfreunde Lotte | 1. FC Köln II | 1-1 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | Rot-Weiss Ahlen | Rot-Weiss Oberhausen | 0-0 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | SV Straelen | FC Schalke 04 II | 2-1 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | Fortuna Düsseldorf II | Bonner SC | 1-2 | 5 - 7 points |
| 3/5/22 7:00 AM | 3/5/22 7:00 AM | FC Wegberg-Beeck | SC Wiedenbrück | 1-0 | 5 - 7 points |
| 3/6/22 7:00 AM | 3/6/22 7:00 AM | Wuppertaler SV | Preußen Münster | 1-1 | 5 - 7 points |
| 4/19/22 12:30 PM | 4/19/22 12:30 PM | Rot-Weiss Essen | SV Lippstadt 08 | 4-0 | 5 - 7 points |