Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/24/21 12:30 PM | 8/24/21 12:30 PM | Bonner SC | SV Straelen | 1-3 | 5 - 7 points |
| 8/25/21 7:00 AM | 8/25/21 7:00 AM | FC Schalke 04 II | Bor. Mönchengladbach II | 1-0 | 5 - 7 points |
| 8/25/21 11:00 AM | 8/25/21 11:00 AM | SV Lippstadt 08 | Alemannia Aachen | 2-0 | 5 - 7 points |
| 8/25/21 11:00 AM | 8/25/21 11:00 AM | Fortuna Düsseldorf II | SV Rödinghausen | 3-1 | 5 - 7 points |
| 8/25/21 12:00 PM | 8/25/21 12:00 PM | Wuppertaler SV | Rot-Weiss Essen | 0-1 | 5 - 7 points |
| 8/25/21 12:30 PM | 8/25/21 12:30 PM | Rot-Weiss Oberhausen | 1. FC Köln II | 1-0 | 5 - 7 points |
| 8/25/21 12:30 PM | 8/25/21 12:30 PM | SC Fortuna Köln | Rot-Weiss Ahlen | 1-1 | 5 - 7 points |
| 8/25/21 12:30 PM | 8/25/21 12:30 PM | VfB Homberg | FC Wegberg-Beeck | 1-1 | 5 - 7 points |
| 8/25/21 12:30 PM | 8/25/21 12:30 PM | KFC Uerdingen | SC Wiedenbrück | 2-3 | 5 - 7 points |
| 8/25/21 12:30 PM | 8/25/21 12:30 PM | Preußen Münster | Sportfreunde Lotte | 2-0 | 5 - 7 points |