Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | Rot-Weiss Essen | KFC Uerdingen | 3-0 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | Sportfreunde Lotte | Bor. Mönchengladbach II | 2-0 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | FC Wegberg-Beeck | Alemannia Aachen | 0-2 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | SV Rödinghausen | 1. FC Köln II | 2-1 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | Rot-Weiss Ahlen | SC Wiedenbrück | 1-0 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | SV Straelen | Rot-Weiss Oberhausen | 1-2 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | Wuppertaler SV | SV Lippstadt 08 | 3-0 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | VfB Homberg | Bonner SC | 0-3 | 5 - 7 points |
| 3/19/22 8:00 AM | 3/19/22 8:00 AM | SC Fortuna Köln | FC Schalke 04 II | 2-2 | 5 - 7 points |
| 3/20/22 8:00 AM | 3/20/22 8:00 AM | Fortuna Düsseldorf II | Preußen Münster | 0-1 | 5 - 7 points |