Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/25/22 8:00 AM | 3/25/22 8:00 AM | FC Schalke 04 II | Fortuna Düsseldorf II | 0-4 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | Rot-Weiss Oberhausen | Wuppertaler SV | 1-1 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | Bor. Mönchengladbach II | FC Wegberg-Beeck | 0-1 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | KFC Uerdingen | SV Straelen | 4-1 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | Preußen Münster | VfB Homberg | 2-0 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | Bonner SC | Sportfreunde Lotte | 0-2 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | SC Wiedenbrück | Rot-Weiss Essen | 0-1 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | 1. FC Köln II | Rot-Weiss Ahlen | 6-1 | 5 - 7 points |
| 3/26/22 8:00 AM | 3/26/22 8:00 AM | SV Lippstadt 08 | SC Fortuna Köln | 0-2 | 5 - 7 points |
| 3/27/22 7:00 AM | 3/27/22 7:00 AM | Alemannia Aachen | SV Rödinghausen | 0-1 | 5 - 7 points |