Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/1/22 12:00 PM | 4/1/22 12:00 PM | VfB Homberg | FC Schalke 04 II | 0-3 | 5 - 7 points |
| 4/1/22 12:30 PM | 4/1/22 12:30 PM | Rot-Weiss Essen | 1. FC Köln II | 2-0 | 5 - 7 points |
| 4/2/22 7:00 AM | 4/2/22 7:00 AM | Preußen Münster | Bonner SC | 3-0 | 5 - 7 points |
| 4/2/22 7:00 AM | 4/2/22 7:00 AM | SC Fortuna Köln | Rot-Weiss Oberhausen | 1-1 | 5 - 7 points |
| 4/2/22 7:00 AM | 4/2/22 7:00 AM | SV Straelen | SC Wiedenbrück | 1-1 | 5 - 7 points |
| 4/2/22 7:00 AM | 4/2/22 7:00 AM | FC Wegberg-Beeck | Sportfreunde Lotte | 1-0 | 5 - 7 points |
| 4/2/22 7:00 AM | 4/2/22 7:00 AM | Fortuna Düsseldorf II | SV Lippstadt 08 | 1-4 | 5 - 7 points |
| 4/13/22 11:30 AM | 4/13/22 11:30 AM | SV Rödinghausen | Bor. Mönchengladbach II | 0-0 | 5 - 7 points |
| 4/20/22 12:00 PM | 4/20/22 12:00 PM | Wuppertaler SV | KFC Uerdingen | 2-0 | 5 - 7 points |
| 4/27/22 12:30 PM | 4/27/22 12:30 PM | Rot-Weiss Ahlen | Alemannia Aachen | 0-2 | 5 - 7 points |