Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/8/22 12:30 PM | 4/8/22 12:30 PM | Rot-Weiss Oberhausen | Fortuna Düsseldorf II | 2-1 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | Sportfreunde Lotte | SV Rödinghausen | 0-1 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | 1. FC Köln II | SV Straelen | 0-0 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | KFC Uerdingen | SC Fortuna Köln | 1-1 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | Bor. Mönchengladbach II | Rot-Weiss Ahlen | 4-1 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | Bonner SC | FC Wegberg-Beeck | 2-0 | 5 - 7 points |
| 4/9/22 7:00 AM | 4/9/22 7:00 AM | SC Wiedenbrück | Wuppertaler SV | 0-1 | 5 - 7 points |
| 4/10/22 7:00 AM | 4/10/22 7:00 AM | FC Schalke 04 II | Preußen Münster | 0-2 | 5 - 7 points |
| 4/10/22 7:00 AM | 4/10/22 7:00 AM | Alemannia Aachen | Rot-Weiss Essen | 1-1 | 5 - 7 points |
| 4/27/22 11:00 AM | 4/27/22 11:00 AM | SV Lippstadt 08 | VfB Homberg | 0-1 | 5 - 7 points |