Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | Rot-Weiss Ahlen | Sportfreunde Lotte | 1-1 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | FC Schalke 04 II | Bonner SC | 1-0 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | SV Straelen | Alemannia Aachen | 0-1 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | VfB Homberg | Rot-Weiss Oberhausen | 0-1 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | SV Lippstadt 08 | Preußen Münster | 3-3 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | SC Fortuna Köln | SC Wiedenbrück | 2-3 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | SV Rödinghausen | FC Wegberg-Beeck | 1-1 | 5 - 7 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | Fortuna Düsseldorf II | KFC Uerdingen | 1-0 | 5 - 7 points |
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | Wuppertaler SV | 1. FC Köln II | 2-0 | 5 - 7 points |
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | Rot-Weiss Essen | Bor. Mönchengladbach II | 1-1 | 5 - 7 points |