Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/22/22 12:30 PM | 4/22/22 12:30 PM | Sportfreunde Lotte | Rot-Weiss Essen | 0-3 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | Bonner SC | SV Rödinghausen | 0-1 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | FC Wegberg-Beeck | Rot-Weiss Ahlen | 0-1 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | 1. FC Köln II | SC Fortuna Köln | 2-2 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | Bor. Mönchengladbach II | SV Straelen | 2-1 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | KFC Uerdingen | VfB Homberg | 0-4 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | SC Wiedenbrück | Fortuna Düsseldorf II | 3-1 | 5 - 7 points |
| 4/23/22 7:00 AM | 4/23/22 7:00 AM | SV Lippstadt 08 | FC Schalke 04 II | 0-1 | 5 - 7 points |
| 4/24/22 7:00 AM | 4/24/22 7:00 AM | Alemannia Aachen | Wuppertaler SV | 1-2 | 5 - 7 points |
| 4/24/22 7:00 AM | 4/24/22 7:00 AM | Rot-Weiss Oberhausen | Preußen Münster | 0-3 | 5 - 7 points |