Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/29/22 7:00 AM | 4/29/22 7:00 AM | Fortuna Düsseldorf II | 1. FC Köln II | 0-1 | 5 - 7 points |
| 4/29/22 12:30 PM | 4/29/22 12:30 PM | Rot-Weiss Essen | FC Wegberg-Beeck | 3-1 | 5 - 7 points |
| 4/29/22 12:30 PM | 4/29/22 12:30 PM | FC Schalke 04 II | Rot-Weiss Oberhausen | 0-1 | 5 - 7 points |
| 4/29/22 12:30 PM | 4/29/22 12:30 PM | Preußen Münster | KFC Uerdingen | 3-0 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | Rot-Weiss Ahlen | SV Rödinghausen | 2-1 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | SV Straelen | Sportfreunde Lotte | 2-1 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | SV Lippstadt 08 | Bonner SC | 1-1 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | SC Fortuna Köln | Alemannia Aachen | 0-0 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | Wuppertaler SV | Bor. Mönchengladbach II | 1-0 | 5 - 7 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | VfB Homberg | SC Wiedenbrück | 2-1 | 5 - 7 points |