Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | SV Rödinghausen | VfB Homberg | 0-1 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | Alemannia Aachen | Rot-Weiss Oberhausen | 1-3 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | Rot-Weiss Ahlen | Fortuna Düsseldorf II | 1-1 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | SV Straelen | Wuppertaler SV | 1-4 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | Sportfreunde Lotte | FC Schalke 04 II | 2-0 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | 1. FC Köln II | KFC Uerdingen | 8-2 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | SC Wiedenbrück | Bonner SC | 3-1 | 5 - 7 points |
| 8/28/21 7:00 AM | 8/28/21 7:00 AM | Bor. Mönchengladbach II | SV Lippstadt 08 | 4-2 | 5 - 7 points |
| 8/29/21 7:00 AM | 8/29/21 7:00 AM | Rot-Weiss Essen | SC Fortuna Köln | 2-1 | 5 - 7 points |
| 8/29/21 7:00 AM | 8/29/21 7:00 AM | FC Wegberg-Beeck | Preußen Münster | 0-4 | 5 - 7 points |