Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | SV Lippstadt 08 | Sportfreunde Lotte | 2-1 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | VfB Homberg | Rot-Weiss Ahlen | 1-2 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | FC Schalke 04 II | FC Wegberg-Beeck | 2-0 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | Rot-Weiss Oberhausen | Bor. Mönchengladbach II | 3-2 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | Preußen Münster | SV Rödinghausen | 0-0 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | KFC Uerdingen | Alemannia Aachen | 0-0 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | SC Fortuna Köln | SV Straelen | 1-0 | 5 - 7 points |
| 9/4/21 7:00 AM | 9/4/21 7:00 AM | Bonner SC | Wuppertaler SV | 1-2 | 5 - 7 points |
| 9/28/21 12:30 PM | 9/28/21 12:30 PM | SC Wiedenbrück | 1. FC Köln II | 2-0 | 5 - 7 points |
| 10/27/21 12:30 PM | 10/27/21 12:30 PM | Fortuna Düsseldorf II | Rot-Weiss Essen | 3-3 | 5 - 7 points |