Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/10/21 11:30 AM | 9/10/21 11:30 AM | SV Rödinghausen | FC Schalke 04 II | 1-0 | 5 - 7 points |
| 9/10/21 12:00 PM | 9/10/21 12:00 PM | Alemannia Aachen | SC Wiedenbrück | 0-1 | 5 - 7 points |
| 9/10/21 12:30 PM | 9/10/21 12:30 PM | 1. FC Köln II | Bonner SC | 3-2 | 5 - 7 points |
| 9/10/21 12:30 PM | 9/10/21 12:30 PM | Rot-Weiss Essen | VfB Homberg | 3-0 | 5 - 7 points |
| 9/10/21 12:30 PM | 9/10/21 12:30 PM | Rot-Weiss Ahlen | Preußen Münster | 1-1 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | FC Wegberg-Beeck | SV Lippstadt 08 | 2-3 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | Wuppertaler SV | SC Fortuna Köln | 1-1 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | SV Straelen | Fortuna Düsseldorf II | 1-1 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | Bor. Mönchengladbach II | KFC Uerdingen | 0-0 | 5 - 7 points |
| 10/27/21 12:30 PM | 10/27/21 12:30 PM | Sportfreunde Lotte | Rot-Weiss Oberhausen | 1-2 | 5 - 7 points |