Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/14/21 11:30 AM | 9/14/21 11:30 AM | SC Wiedenbrück | Bor. Mönchengladbach II | 0-0 | 5 - 7 points |
| 9/14/21 12:00 PM | 9/14/21 12:00 PM | Preußen Münster | Rot-Weiss Essen | 2-3 | 5 - 7 points |
| 9/14/21 12:30 PM | 9/14/21 12:30 PM | FC Schalke 04 II | Rot-Weiss Ahlen | 5-3 | 5 - 7 points |
| 9/15/21 11:00 AM | 9/15/21 11:00 AM | SV Lippstadt 08 | SV Rödinghausen | 0-2 | 5 - 7 points |
| 9/15/21 12:00 PM | 9/15/21 12:00 PM | Fortuna Düsseldorf II | Wuppertaler SV | 1-2 | 5 - 7 points |
| 9/15/21 12:30 PM | 9/15/21 12:30 PM | Bonner SC | SC Fortuna Köln | 0-2 | 5 - 7 points |
| 9/15/21 12:30 PM | 9/15/21 12:30 PM | Rot-Weiss Oberhausen | FC Wegberg-Beeck | 0-0 | 5 - 7 points |
| 9/15/21 12:30 PM | 9/15/21 12:30 PM | 1. FC Köln II | Alemannia Aachen | 1-3 | 5 - 7 points |
| 10/6/21 12:30 PM | 10/6/21 12:30 PM | VfB Homberg | SV Straelen | 0-1 | 5 - 7 points |
| 10/6/21 12:30 PM | 10/6/21 12:30 PM | KFC Uerdingen | Sportfreunde Lotte | 2-0 | 5 - 7 points |