Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/2/22 12:30 PM | 9/2/22 12:30 PM | SC Fortuna Köln | 1. FC Kaan-Marienborn | 3-0 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | Wuppertaler SV | SV Straelen | 2-1 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | Fortuna Düsseldorf II | SV Lippstadt 08 | 3-1 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | 1. FC Düren | SV Rödinghausen | 0-2 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | Rot-Weiss Ahlen | Bor. Mönchengladbach II | 1-2 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | Preußen Münster | 1. FC Köln II | 4-2 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | Rot-Weiss Oberhausen | FC Schalke 04 II | 1-3 | 5 - 7 points |
| 9/3/22 7:00 AM | 9/3/22 7:00 AM | SC Wiedenbrück | 1. FC Bocholt | 2-1 | 5 - 7 points |
| 9/4/22 7:00 AM | 9/4/22 7:00 AM | SG Wattenscheid 09 | Alemannia Aachen | 1-2 | 5 - 7 points |