Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 12:30 PM | 9/17/21 12:30 PM | Rot-Weiss Essen | FC Schalke 04 II | 1-0 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Wuppertaler SV | VfB Homberg | 3-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | FC Wegberg-Beeck | KFC Uerdingen | 1-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | SV Straelen | Preußen Münster | 0-4 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Bor. Mönchengladbach II | 1. FC Köln II | 3-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Rot-Weiss Oberhausen | SV Rödinghausen | 2-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Rot-Weiss Ahlen | SV Lippstadt 08 | 1-1 | 5 - 7 points |
| 9/19/21 7:00 AM | 9/19/21 7:00 AM | SC Fortuna Köln | Fortuna Düsseldorf II | 0-0 | 5 - 7 points |
| 9/19/21 7:00 AM | 9/19/21 7:00 AM | Bonner SC | Alemannia Aachen | 1-1 | 5 - 7 points |
| 11/10/21 12:30 PM | 11/10/21 12:30 PM | Sportfreunde Lotte | SC Wiedenbrück | 0-2 | 5 - 7 points |