Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | SV Lippstadt 08 | Rot-Weiss Essen | 1-2 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | FC Schalke 04 II | SV Straelen | 1-1 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | Rot-Weiss Oberhausen | Rot-Weiss Ahlen | 4-0 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | Bonner SC | Fortuna Düsseldorf II | 0-3 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | VfB Homberg | SC Fortuna Köln | 0-0 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | SC Wiedenbrück | FC Wegberg-Beeck | 1-1 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | KFC Uerdingen | SV Rödinghausen | 1-2 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | 1. FC Köln II | Sportfreunde Lotte | 4-0 | 5 - 7 points |
| 9/25/21 9:00 AM | 9/25/21 9:00 AM | Alemannia Aachen | Bor. Mönchengladbach II | 0-1 | 5 - 7 points |
| 9/26/21 7:00 AM | 9/26/21 7:00 AM | Preußen Münster | Wuppertaler SV | 0-0 | 5 - 7 points |