| Date | Home | Away | Result |
|---|---|---|---|
| 2/25/21 6:30 PM | Red Bull Bragantino | Gremio Porto Alegre | 1-0 |
| 2/25/21 6:30 PM | Athletico Paranaense | Sport Recife | 2-0 |
| 2/25/21 6:30 PM | Atletico Goianiense | Coritiba | 3-1 |
| 2/25/21 6:30 PM | Vasco da Gama RJ | Goias EC | 3-2 |
| 2/25/21 6:30 PM | Club Atletico Mineiro | Palmeiras | 2-0 |
| 2/25/21 6:30 PM | Fluminense | Fortaleza | 2-0 |
| 2/25/21 6:30 PM | Bahia BA | FC Santos | 2-0 |
| 2/25/21 6:30 PM | Internacional | Corinthians | 0-0 |
| 2/25/21 6:30 PM | Ceará | Botafogo | 2-1 |
| 2/25/21 6:30 PM | FC Sao Paulo | Flamengo | 2-1 |