| Date | Home | Away | Result |
|---|---|---|---|
| 12/9/21 6:30 PM | Sport Recife | Athletico Paranaense | 1-1 |
| 12/9/21 6:30 PM | Red Bull Bragantino | Internacional | 1-0 |
| 12/9/21 6:30 PM | Gremio Porto Alegre | Club Atletico Mineiro | 4-3 |
| 12/9/21 6:30 PM | FC Santos | Cuiaba EC | 1-1 |
| 12/9/21 6:30 PM | Fluminense | AF Chapecoense | 3-0 |
| 12/9/21 6:30 PM | EC Juventude | Corinthians | 1-0 |
| 12/9/21 6:30 PM | America FC | FC Sao Paulo | 2-0 |
| 12/9/21 6:30 PM | Fortaleza | Bahia BA | 2-1 |
| 12/9/21 6:30 PM | Palmeiras | Ceará | 1-0 |
| 12/9/21 6:30 PM | Atletico Goianiense | Flamengo | 2-0 |