| Date | Home | Away | Result |
|---|---|---|---|
| 5/8/21 6:30 AM | Nottingham Forest | Preston North End | 1-2 |
| 5/8/21 6:30 AM | Reading FC | Huddersfield Town | 2-2 |
| 5/8/21 6:30 AM | Blackburn Rovers | Birmingham City | 5-2 |
| 5/8/21 6:30 AM | Queens Park Rangers | Luton Town | 3-1 |
| 5/8/21 6:30 AM | Cardiff City | Rotherham United | 1-1 |
| 5/8/21 6:30 AM | Derby County | Sheffield Wednesday | 3-3 |
| 5/8/21 6:30 AM | Watford FC | Swansea City | 2-0 |
| 5/8/21 6:30 AM | Coventry City | Millwall FC | 6-1 |
| 5/8/21 6:30 AM | Bristol City | Brentford FC | 1-3 |
| 5/8/21 6:30 AM | AFC Bournemouth | Stoke City | 0-2 |
| 5/8/21 6:30 AM | Middlesbrough FC | Wycombe Wanderers | 0-3 |
| 5/8/21 6:30 AM | Barnsley FC | Norwich City | 2-2 |