| Date | Home | Away | Result |
|---|---|---|---|
| 5/15/21 1:00 PM | USL Dunkerque | FC Toulouse | 3-3 |
| 5/15/21 1:00 PM | Pau FC | Valenciennes FC | 4-3 |
| 5/15/21 1:00 PM | SM Caen | Clermont Foot | 2-1 |
| 5/15/21 1:00 PM | Chamois Niortais FC | EA Guingamp | 0-2 |
| 5/15/21 1:00 PM | LB Chateauroux | AC Ajaccio | 0-0 |
| 5/15/21 1:00 PM | Paris FC | FC Chambly | 3-0 |
| 5/15/21 1:00 PM | FC Sochaux | AJ Auxerre | 2-3 |
| 5/15/21 1:00 PM | AS Nancy-Lorraine | Amiens SC | 2-2 |
| 5/15/21 1:00 PM | Havre AC | ES Troyes AC | 3-2 |
| 5/15/21 1:00 PM | Grenoble Foot | Rodez Aveyron | 1-0 |