| Date | Home | Away | Result |
|---|---|---|---|
| 5/14/22 12:00 PM | FC Sochaux | Dijon FCO | 2-2 |
| 5/14/22 12:00 PM | AC Ajaccio | FC Toulouse | 1-0 |
| 5/14/22 12:00 PM | AJ Auxerre | Amiens SC | 2-1 |
| 5/14/22 12:00 PM | EA Guingamp | Havre AC | 2-1 |
| 5/14/22 12:00 PM | AS Nancy-Lorraine | Pau FC | 2-3 |
| 5/14/22 12:00 PM | Chamois Niortais FC | Valenciennes FC | 1-2 |
| 5/14/22 12:00 PM | Paris FC | Grenoble Foot | 2-0 |
| 5/14/22 12:00 PM | Nimes Olympique | SC Bastia | 0-2 |
| 5/14/22 12:00 PM | US Quevilly Rouen | USL Dunkerque | 3-1 |
| 5/14/22 12:00 PM | Rodez Aveyron | SM Caen | 2-0 |