| Date | Home | Away | Result |
|---|---|---|---|
| 5/13/18 6:00 AM | CSKA Moscow | Anschi Machatschkala | 2-1 |
| 5/13/18 6:00 AM | FK Ufa | FK Tosno | 5-0 |
| 5/13/18 6:00 AM | Spartak Moscow | Dynamo Moscow | 0-1 |
| 5/13/18 6:00 AM | Arsenal Tula | Lokomotive Moscow | 2-0 |
| 5/13/18 6:00 AM | FK Rostow | Ural Jekaterinburg | 1-0 |
| 5/13/18 6:00 AM | Amkar Perm | Achmat Grosny | 0-0 |
| 5/13/18 6:00 AM | Zenit St. Petersburg | SKA-Energija Chabarowsk | 6-0 |
| 5/13/18 6:00 AM | FK Krasnodar | Rubin Kasan | 1-1 |