| Date | Home | Away | Result |
|---|---|---|---|
| 5/21/22 9:00 AM | FK Krasnodar | Achmat Grosny | 1-1 |
| 5/21/22 9:00 AM | CSKA Moscow | FK Rostow | 4-0 |
| 5/21/22 9:00 AM | Dynamo Moscow | PFC Sochi | 1-5 |
| 5/21/22 9:00 AM | FK Nischni Nowgorod | Zenit St. Petersburg | 1-0 |
| 5/21/22 9:00 AM | FC Krylia Sovetov Samara | Lokomotive Moscow | 0-1 |
| 5/21/22 9:00 AM | Rubin Kasan | FK Ufa | 1-2 |
| 5/21/22 9:00 AM | Arsenal Tula | Ural Jekaterinburg | 1-2 |
| 5/21/22 9:00 AM | FK Chimki | Spartak Moscow | 2-1 |