| Date | Home | Away | Result |
|---|---|---|---|
| 5/18/21 2:15 PM | CD Tondela | FC Pacos de Ferreira | 2-3 |
| 5/19/21 12:00 PM | FC Porto | Belenenses Lisbon | 4-0 |
| 5/19/21 2:00 PM | Portimonense | Sporting Braga | 0-0 |
| 5/19/21 2:00 PM | Moreirense FC | FC Famalicao | 3-0 |
| 5/19/21 2:00 PM | Nacional Funchal | Rio Ave FC | 1-2 |
| 5/19/21 2:00 PM | Santa Clara | SC Farense | 4-0 |
| 5/19/21 2:00 PM | FC Gil Vicente | Boavista Porto | 1-2 |
| 5/19/21 2:00 PM | Vitoria Guimaraes | Benfica Lisbon | 1-3 |
| 5/19/21 3:45 PM | Sporting Lisbon | Maritimo Funchal | 5-1 |