| Date | Home | Away | Result |
|---|---|---|---|
| 5/13/22 2:15 PM | FC Pacos de Ferreira | Benfica Lisbon | 0-2 |
| 5/14/22 9:30 AM | CD Tondela | Boavista Porto | 2-2 |
| 5/14/22 9:30 AM | FC Arouca | Belenenses Lisbon | 0-0 |
| 5/14/22 9:30 AM | Moreirense FC | FC Vizela | 4-1 |
| 5/14/22 12:00 PM | Maritimo Funchal | Portimonense | 0-1 |
| 5/14/22 12:00 PM | FC Porto | Estoril Praia | 2-0 |
| 5/14/22 2:30 PM | Sporting Lisbon | Santa Clara | 4-0 |
| 5/15/22 12:00 PM | FC Famalicao | Sporting Braga | 3-2 |
| 5/15/22 2:30 PM | Vitoria Guimaraes | FC Gil Vicente | 5-0 |