| Date | Home | Away | Result |
|---|---|---|---|
| 2/13/21 3:30 PM | Unión La Calera | Curico Unido | 2-3 |
| 2/13/21 3:30 PM | Universidad de Chile | CD Antofagasta | 3-1 |
| 2/14/21 7:30 AM | Universidad de Concepcion | Universidad Católica | 1-2 |
| 2/14/21 7:30 AM | Everton | Huachipato | 1-0 |
| 2/14/21 3:00 PM | Iquique | Santiago Wanderers | 2-0 |
| 2/14/21 3:00 PM | Deportes La Serena | Audax Italiano | 0-2 |
| 2/14/21 3:00 PM | Palestino | Coquimbo Unido | 2-2 |
| 2/14/21 3:00 PM | O'Higgins | Colo-Colo | 1-1 |
| 2/15/21 7:30 AM | Cobresal | Unión Española | 4-1 |