| Date | Home | Away | Result |
|---|---|---|---|
| 11/5/22 10:30 AM | Palestino | Huachipato | 5-0 |
| 11/5/22 10:30 AM | Universidad de Chile | Cobresal | 3-4 |
| 11/5/22 10:30 AM | O'Higgins | Everton | 2-0 |
| 11/6/22 1:00 PM | Audax Italiano | Deportes La Serena | 3-0 |
| 11/6/22 1:00 PM | Ñublense | Colo-Colo | 1-1 |
| 11/6/22 1:00 PM | Coquimbo Unido | Curico Unido | 1-1 |
| 11/6/22 1:00 PM | CD Antofagasta | Universidad Católica | 0-2 |
| 11/6/22 4:00 PM | Unión La Calera | Unión Española | 2-1 |