| Date | Home | Away | Result |
|---|---|---|---|
| 6/1/18 2:00 PM | La Hoya Lorca | Sevilla Atlético | 2-1 |
| 6/2/18 1:30 PM | CD Teneriffa | Albacete Balompie | 1-1 |
| 6/2/18 1:30 PM | AD Alcorcon | CF Reus Deportiu | 3-0 |
| 6/2/18 1:30 PM | Real Oviedo | SD Huesca | 2-1 |
| 6/2/18 1:30 PM | Cordoba CF | Sporting Gijon | 3-0 |
| 6/2/18 1:30 PM | FC Barcelona B | Real Saragossa | 0-2 |
| 6/2/18 1:30 PM | CD Lugo | UD Almeria | 1-1 |
| 6/2/18 1:30 PM | Gimnastic de Tarragona | Rayo Vallecano | 2-0 |
| 6/2/18 1:30 PM | CD Numancia | Cultural y Deportiva Leonesa | 2-1 |
| 6/2/18 1:30 PM | Real Valladolid | CA Osasuna | 2-0 |
| 6/2/18 1:30 PM | FC Granada | FC Cadiz | 2-1 |