| Date | Home | Away | Result |
|---|---|---|---|
| 5/29/21 11:30 AM | CD Teneriffa | Real Oviedo | 2-2 |
| 5/30/21 11:30 AM | Albacete Balompie | CF Fuenlabrada | 1-2 |
| 5/30/21 2:00 PM | CD Mirandes | CD Sabadell | 0-2 |
| 5/30/21 2:00 PM | FC Cartagena | FC Girona | 1-1 |
| 5/30/21 2:00 PM | Rayo Vallecano | CD Lugo | 0-1 |
| 5/30/21 2:00 PM | FC Malaga | CD Castellon | 3-0 |
| 5/30/21 2:00 PM | SD Ponferradina | RCD Mallorca | 2-2 |
| 5/30/21 2:00 PM | AD Alcorcon | Espanyol Barcelona | 1-0 |
| 5/30/21 2:00 PM | UD Logrones | UD Las Palmas | 0-1 |
| 5/30/21 2:00 PM | Real Saragossa | CD Leganes | 0-5 |
| 5/30/21 2:00 PM | Sporting Gijon | UD Almeria | 0-2 |