| Date | Home | Away | Result |
|---|---|---|---|
| 5/27/22 2:00 PM | Real Sociedad B | Real Saragossa | 1-2 |
| 5/27/22 2:00 PM | CD Mirandes | CF Fuenlabrada | 5-1 |
| 5/28/22 11:15 AM | SD Amorebieta | SD Ponferradina | 1-0 |
| 5/28/22 11:15 AM | CD Lugo | FC Malaga | 1-0 |
| 5/29/22 1:00 PM | Burgos CF | FC Girona | 0-0 |
| 5/29/22 1:00 PM | CD Leganes | UD Almeria | 2-2 |
| 5/29/22 1:00 PM | Real Oviedo | UD Ibiza Eivissa | 3-2 |
| 5/29/22 1:00 PM | Sporting Gijon | UD Las Palmas | 0-1 |
| 5/29/22 1:00 PM | AD Alcorcon | SD Eibar | 1-0 |
| 5/29/22 1:00 PM | CD Teneriffa | FC Cartagena | 1-2 |
| 5/29/22 1:00 PM | Real Valladolid | SD Huesca | 3-0 |