| Date | Home | Away | Result |
|---|---|---|---|
| 5/6/22 11:15 AM | FC Crotone | Parma Calcio 1913 | 0-1 |
| 5/6/22 1:30 PM | Cosenza Calcio | AS Cittadella | 1-0 |
| 5/6/22 1:30 PM | Frosinone Calcio | AC Pisa | 1-2 |
| 5/6/22 1:30 PM | Como Calcio | US Cremonese | 1-2 |
| 5/6/22 1:30 PM | AC Perugia | AC Monza | 1-0 |
| 5/6/22 1:30 PM | US Lecce | Pordenone | 1-0 |
| 5/6/22 1:30 PM | Benevento Calcio | SPAL Ferrara | 1-2 |
| 5/6/22 1:30 PM | Ascoli Calcio | Ternana Calcio | 4-1 |
| 5/6/22 1:30 PM | Alessandria Calcio | Vicenza Calcio | 0-1 |
| 5/6/22 1:30 PM | Brescia Calcio | Reggina 1914 | 3-0 |