| Date | Home | Away | Result |
|---|---|---|---|
| 5/22/21 1:45 PM | Cagliari Calcio | FC Genua 1893 | 0-1 |
| 5/22/21 1:45 PM | FC Crotone | Fiorentina | 0-0 |
| 5/22/21 1:45 PM | Sampdoria Genua | Parma Calcio 1913 | 3-0 |
| 5/23/21 8:00 AM | Inter Milan | Udinese Calcio | 5-1 |
| 5/23/21 1:45 PM | Spezia Calcio | AS Roma | 2-2 |
| 5/23/21 1:45 PM | Atalanta Bergamo | AC Milan | 0-2 |
| 5/23/21 1:45 PM | FC Bologna | Juventus Turin | 1-4 |
| 5/23/21 1:45 PM | Sassuolo Calcio | Lazio Rom | 2-0 |
| 5/23/21 1:45 PM | SSC Napoli | Hellas Verona | 1-1 |
| 5/23/21 1:45 PM | FC Turin | Benevento Calcio | 1-1 |