| Date | Home | Away | Result |
|---|---|---|---|
| 5/22/11 4:00 PM | FC Genua 1893 | FC Cesena | 3-2 |
| 5/22/11 4:00 PM | Inter Milan | Catania Calcio | 3-1 |
| 5/22/11 4:00 PM | Brescia Calcio | Fiorentina | 2-2 |
| 5/22/11 4:00 PM | FC Bologna | AS Bari | 0-4 |
| 5/22/11 4:00 PM | US Palermo | AC Chievo Verona | 1-3 |
| 5/22/11 4:00 PM | Cagliari Calcio | Parma Calcio 1913 | 1-1 |
| 5/22/11 6:45 PM | Juventus Turin | SSC Napoli | 2-2 |
| 5/22/11 6:45 PM | Udinese Calcio | AC Milan | 0-0 |
| 5/22/11 6:45 PM | AS Roma | Sampdoria Genua | 3-1 |
| 5/22/11 6:45 PM | US Lecce | Lazio Rom | 2-4 |