| Date | Home | Away | Result |
|---|---|---|---|
| 5/20/22 1:45 PM | FC Turin | AS Roma | 0-3 |
| 5/21/22 10:15 AM | FC Genua 1893 | FC Bologna | 0-1 |
| 5/21/22 1:45 PM | Lazio Rom | Hellas Verona | 3-3 |
| 5/21/22 1:45 PM | Fiorentina | Juventus Turin | 2-0 |
| 5/21/22 1:50 PM | Atalanta Bergamo | FC Empoli | 0-1 |
| 5/22/22 5:30 AM | Spezia Calcio | SSC Napoli | 0-3 |
| 5/22/22 11:00 AM | Sassuolo Calcio | AC Milan | 0-3 |
| 5/22/22 11:05 AM | Inter Milan | Sampdoria Genua | 3-0 |
| 5/22/22 2:00 PM | US Salernitana | Udinese Calcio | 0-4 |
| 5/22/22 2:00 PM | FC Venice | Cagliari Calcio | 0-0 |