| Date | Home | Away | Result |
|---|---|---|---|
| 5/6/18 7:30 AM | Roda JC Kerkrade | ADO Den Haag | 2-3 |
| 5/6/18 7:30 AM | SC Heerenveen | Feyenoord Rotterdam | 2-3 |
| 5/6/18 7:30 AM | Sparta Rotterdam | Heracles Almelo | 2-5 |
| 5/6/18 7:30 AM | PSV Eindhoven | FC Groningen | 0-0 |
| 5/6/18 7:30 AM | FC Twente Enschede | NAC Breda | 1-1 |
| 5/6/18 7:30 AM | FC Utrecht | VVV Venlo | 1-0 |
| 5/6/18 7:30 AM | Willem II Tilburg | Vitesse Arnheim | 2-2 |
| 5/6/18 7:30 AM | Excelsior Rotterdam | Ajax Amsterdam | 1-2 |
| 5/6/18 7:30 AM | AZ Alkmaar | PEC Zwolle | 6-0 |