| Date | Home | Away | Result |
|---|---|---|---|
| 5/16/21 7:30 AM | PEC Zwolle | FC Groningen | 1-0 |
| 5/16/21 7:30 AM | VVV Venlo | FC Emmen | 0-4 |
| 5/16/21 7:30 AM | AZ Alkmaar | Heracles Almelo | 5-0 |
| 5/16/21 7:30 AM | SC Heerenveen | Sparta Rotterdam | 1-2 |
| 5/16/21 7:30 AM | FC Utrecht | PSV Eindhoven | 1-1 |
| 5/16/21 7:30 AM | FC Twente Enschede | ADO Den Haag | 3-2 |
| 5/16/21 7:30 AM | Feyenoord Rotterdam | RKC Waalwijk | 3-0 |
| 5/16/21 7:30 AM | Willem II Tilburg | Fortuna Sittard | 2-1 |
| 5/16/21 7:30 AM | Vitesse Arnheim | Ajax Amsterdam | 1-3 |