| Date | Home | Away | Result |
|---|---|---|---|
| 5/21/21 2:00 PM | UD Levante | FC Cadiz | 2-2 |
| 5/22/21 11:00 AM | Real Valladolid | Atletico Madrid | 1-2 |
| 5/22/21 11:00 AM | Real Madrid | FC Villarreal | 2-1 |
| 5/22/21 11:00 AM | SD Huesca | FC Valencia | 0-0 |
| 5/22/21 11:00 AM | CA Osasuna | Real Sociedad | 0-1 |
| 5/22/21 11:00 AM | Celta Vigo | Real Betis Sevilla | 2-3 |
| 5/22/21 11:00 AM | FC Elche | Athletic Bilbao | 2-0 |
| 5/22/21 11:00 AM | SD Eibar | FC Barcelona | 0-1 |
| 5/23/21 11:30 AM | FC Granada | FC Getafe | 0-0 |
| 5/23/21 2:00 PM | FC Sevilla | Deportivo Alaves | 1-0 |