| Date | Home | Away | Result |
|---|---|---|---|
| 5/15/10 11:00 AM | Athletic Bilbao | Deportivo La Coruna | 2-0 |
| 5/15/10 1:00 PM | Atletico Madrid | FC Getafe | 0-3 |
| 5/15/10 1:00 PM | Real Saragossa | FC Villarreal | 3-3 |
| 5/15/10 3:00 PM | UD Almeria | FC Sevilla | 2-3 |
| 5/15/10 3:00 PM | RCD Mallorca | Espanyol Barcelona | 2-0 |
| 5/16/10 12:00 PM | Racing Santander | Sporting Gijon | 2-0 |
| 5/16/10 12:00 PM | FC Barcelona | Real Valladolid | 4-0 |
| 5/16/10 12:00 PM | FC Valencia | CD Teneriffa | 1-0 |
| 5/16/10 12:00 PM | CA Osasuna | Deportivo Xerez | 1-1 |
| 5/16/10 12:00 PM | FC Malaga | Real Madrid | 1-1 |