| Date | Home | Away | Result |
|---|---|---|---|
| 5/20/22 2:00 PM | Real Madrid | Real Betis Sevilla | 0-0 |
| 5/20/22 2:00 PM | Rayo Vallecano | UD Levante | 2-4 |
| 5/21/22 10:30 AM | FC Valencia | Celta Vigo | 2-0 |
| 5/22/22 10:30 AM | FC Elche | FC Getafe | 3-1 |
| 5/22/22 1:00 PM | Deportivo Alaves | FC Cadiz | 0-1 |
| 5/22/22 1:00 PM | FC Granada | Espanyol Barcelona | 0-0 |
| 5/22/22 1:00 PM | CA Osasuna | RCD Mallorca | 0-2 |
| 5/22/22 3:00 PM | FC Barcelona | FC Villarreal | 0-2 |
| 5/22/22 3:00 PM | Real Sociedad | Atletico Madrid | 1-2 |
| 5/22/22 3:00 PM | FC Sevilla | Athletic Bilbao | 1-0 |